Peptide entry
MOTS-c
Evidence / context
Evidence: Limited. Mitochondrial and metabolic-support use is best judged by repeatable response.
Available vial formats
- Conservative 2.5 mg per injection, 2-3x/week (19 units per injection)
- Standard 5 mg per injection, 2-3x/week (38 units per injection)
- Aggressive 5 mg per injection once daily short-term only (38 units per injection), or 10 mg per injection 1-2x/week only if clearly tolerated (75 units per injection)
- Cycle length 2-6 weeks; keep aggressive blocks short and reassess.
- Best timing Morning or pre-workout.
- Conservative 2.5 mg per injection, 2-3x/week (50 units per injection)
- Standard 5 mg per injection, 2-3x/week (100 units per injection)
- Aggressive 5 mg per injection once daily short-term only (100 units per injection), or 10 mg per injection 1-2x/week only if clearly tolerated (200 units per injection)
- Cycle length 2-6 weeks; keep aggressive blocks short and reassess.
- Best timing Morning or pre-workout.
Reconstitution
- Swab vial tops with alcohol
- For 40 mg vial, add 3.0 mL bacteriostatic water slowly
- For 10 mg vial, add 2.0 mL bacteriostatic water slowly
- Inject slowly down vial wall (don't blast powder)
- Gently swirl - do not shake
- Rest 5-10 min to dissolve
- Refrigerate 2-8 C
Dosing, cycle & timing
- Conservative 2.5 mg per injection, 2-3x/week
- Standard 5 mg per injection, 2-3x/week
- Aggressive 5 mg per injection once daily short-term only, or 10 mg per injection 1-2x/week only if clearly tolerated
- Cycle length 2-6 weeks; keep aggressive blocks short and reassess.
- Best timing Morning or pre-workout.
Timing: Avoid late evening if it causes stimulation or sleep disruption.
Support / expected effects
- Insulin sensitivity/fuel partitioning support.
- Often reported: endurance/recovery.
- Fat oxidation/metabolic flexibility support.
Side effects / tolerability
- Warmth/flushing.
- Mild nausea.
- Fatigue if overdosed.
Practical tips
- Start low if nausea/fatigue occurs.
- Pairs well with NAD+ and L-carnitine.
- Consistency > daily high dose for most.
- 10 mg and 40 mg vials use the same biological dose range; vial size only changes concentration and units draw.
Storage
Refrigerated: ~45-60 days.
Related peptides
Related goal guides
Related categories
FAQ
What is MOTS-c explored for?
Insulin sensitivity/fuel partitioning support. Often reported: endurance/recovery. Fat oxidation/metabolic flexibility support.
How is MOTS-c reconstituted?
1) Swab vial tops with alcohol 2) For 40 mg vial, add 3.0 mL bacteriostatic water slowly 3) For 10 mg vial, add 2.0 mL bacteriostatic water slowly 4) Inject slowly down vial wall (don't blast powder) 5) Gently swirl - do not shake 6) Rest 5-10 min to dissolve 7) Refrigerate 2-8 C
What is a typical cycle length for MOTS-c?
2-6 weeks; keep aggressive blocks short and reassess.
How are doses measured in syringe units here?
Units mean U-100 insulin-syringe gradations (1 mL = 100 units), not International Units. Use the calculator only when the vial concentration and injection volume are known.